Stephen Gruber Lab
Research Lab Overview
Our lab utilizes statistical modeling to understand the development of colorectal cancers in different populations, such as the Ashkenazi Jewish community. Our research specializes in cancer risks related to the APC I1307K founder mutation.
We are a collaborating site to The Li-Fraumeni & TP53: Understanding & Progress (LiFT UP) study, an international effort to better understand cancer risk, modifiers of risk, and clinical outcomes for individuals and families with mutations, variants and pathogenic variants in the TP53 gene.
An internationally recognized cancer geneticist and oncologist, Stephen Gruber, M.D., Ph.D., M.P.H., leads City of Hope's Center for Precision Medicine and is a principal investigator for Cancer Genetics Research Registry, a cornerstone of our Clinical Cancer Genomics Community Research Network.
Lab Members
Join one of our labs and help us on our mission to save lives.
Lab Alumni
- Crystal Adams — Reno, Nevada
- Kandace Amend — Optum Health
- Erin Blake — Presbyterian Healthcare Services
- Chase Bowen — University of Texas
- Marci Ciccone — University of Southern California
- Talie Cloud — Health Plan of San Mateo
- Michelle Cote — Karmanos Cancer Center, Wayne State University
- Jonathan Dakubo — University of Ghana
- Michele Gornick — University of Michigan
- Sharon Hensley-Alford — Henry Ford Health System
- Maria Dolores Iniesta — MD Anderson
- Joanne Jeter — University of Utah
- Kirsten Kangelaris — University of San Francisco
- Charalampos Lazaris — Massachusetts Institute of Technology
- Asaf Maoz — Dana Farber Cancer Institute
- Marilena Melas — New York University Genome Center
- Leah Naghi — City of Hope
- Bethany Niell — Moffitt Cancer Center
- Jen Poynter — University of Minnesota
- Blake Powell — Tulane University
- Kristen Purrington — Karmanos Cancer Center, Wayne State University
- Chenxu Qu — Beijing, China
- Leon Raskin — Abbvie
- Laura Rozek — Georgetown University
- Sumita Roy — Wayne State University
- Jewel Samadder — Mayo Clinic
- Stephanie Schmit — Cleveland Clinic
- Sana Shakour — University of Michigan
- Eduardo Villar — MD Anderson
- Joann Yuan — Optum Health
Partnerships
We collaborate with organizations in progressing the development of new treatments in our specialized areas of research.
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Contribute to our discoveries by donating.
Our Publications
Fernandez-Rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-Obrero, V., Hsu, L., Fernandez-Tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-Shaw, P., Shu, X. O., Long, J., Cai, Q., … Peters, U. (2023).
Murphy, N., Song, M., Papadimitriou, N., Carreras-Torres, R., Langenberg, C., Martin, R. M., Tsilidis, K. K., Barroso, I., Chen, J., Frayling, T. M., Bull, C. J., Vincent, E. E., Cotterchio, M., Gruber, S. B., Pai, R. K., Newcomb, P. A., Perez-Cornago, A., van Duijnhoven, F. J. B., Van Guelpen, B., Vodicka, P., … Gunter, M. J. (2022).
McDonnell, K. J., Chemler, J. A., Bartels, P. L., O'Brien, E., Marvin, M. L., Ortega, J., Stern, R. H., Raskin, L., Li, G. M., Sherman, D. H., Barton, J. K., & Gruber, S. B. (2018).
Glatz, A. C., Purrington, K. S., Klinger, A., King, A. R., Hellinger, J., Zhu, X., Gruber, S. B., & Gruber, P. J. (2014).
Stevens, K. N., Hakonarson, H., Kim, C. E., Doevendans, P. A., Koeleman, B. P., Mital, S., Raue, J., Glessner, J. T., Coles, J. G., Moreno, V., Granger, A., Gruber, S. B., & Gruber, P. J. (2010).
Niell, B. L., Long, J. C., Rennert, G., & Gruber, S. B. (2003).
Gruber, S. B., Ellis, N. A., Scott, K. K., Almog, R., Kolachana, P., Bonner, J. D., Kirchhoff, T., Tomsho, L. P., Nafa, K., Pierce, H., Low, M., Satagopan, J., Rennert, H., Huang, H., Greenson, J. K., Groden, J., Rapaport, B., Shia, J., Johnson, S., Gregersen, P. K., … Offit, K. (2002).
Laken, S. J., Petersen, G. M., Gruber, S. B., Oddoux, C., Ostrer, H., Giardiello, F. M., Hamilton, S. R., Hampel, H., Markowitz, A., Klimstra, D., Jhanwar, S., Winawer, S., Offit, K., Luce, M. C., Kinzler, K. W., & Vogelstein, B. (1997).
Latest Research News
External Publications
Precision medicine for all: cancer centre makes genomic analysis a top priority, Nature Portfolio
Contact Information
34.1293487, -117.9726643
Duarte , CA 91010