Our lab utilizes statistical modeling to understand the development of colorectal cancers in different populations, such as the Ashkenazi Jewish community. Our research specializes in cancer risks related to the APC I1307K founder mutation.
We are a collaborating site to The Li-Fraumeni & TP53: Understanding & Progress (LiFT UP) study, an international effort to better understand cancer risk, modifiers of risk, and clinical outcomes for individuals and families with mutations, variants and pathogenic variants in the TP53 gene.
Principal Investigator: Stephen Gruber, M.D., Ph.D., M.P.H.
Associate Director, Division of Clinical Cancer Genomics
Recruited to the Department of Medical Oncology in November 2021 from The Ohio State University Comprehensive Cancer Center, Heather Hampel is an internationally-recognized cancer genetic counselor and researcher with a particular emphasis on universal tumor screening of all colorectal and endometrial cancer patients for Lynch Syndrome.
Dr. Idos is a board-certified gastroenterologist and trained cancer geneticist who specializes in caring for patients with Lynch syndrome, FAP (familial adenomatous polyposis) and other inherited syndromes. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.
Dr. McDonnell specializes in medical oncology and clinical cancer genetics. Named a Top Cancer Doctor by Los Angeles Magazine, Dr. McDonnell brings more than two decades of expertise to his current role at City of Hope.
Ilana Solomon, Sc.M., CGC, is manager of the Precision Medicine Program and a licensed board-certified genetic counselor specializing in cancer genetics. She received her master’s degree in genetic counseling from the Johns Hopkins/National Human Genome Research Institute. Ilana joined City of Hope's Division of Clinical Cancer Genomics in 2013, where she provides cancer genetics services for patients and families suspected of having a hereditary predisposition to cancer. Since 2019, she has also managed and developed City of Hope’s Precision Medicine Program to provide all City of Hope patients with genomic-driven care.
Ilana has research interests in health care communication and implementation, genetic literacy, and ELSI in genomics. She helped co-develop Helping Oncology Patients Explore (HOPE) Genomics: a patient-directed IT platform for cancer genome sequencing education and return of results. She is faculty for City of Hope's Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
Associations between glycemic traits and colorectal cancer: a Mendelian randomization analysis.
Murphy, N., Song, M., Papadimitriou, N., Carreras-Torres, R., Langenberg, C., Martin, R. M., Tsilidis, K. K., Barroso, I., Chen, J., Frayling, T. M., Bull, C. J., Vincent, E. E., Cotterchio, M., Gruber, S. B., Pai, R. K., Newcomb, P. A., Perez-Cornago, A., van Duijnhoven, F. J. B., Van Guelpen, B., Vodicka, P., … Gunter, M. J. (2022).
BLM heterozygosity and the risk of colorectal cancer.
Gruber, S. B., Ellis, N. A., Scott, K. K., Almog, R., Kolachana, P., Bonner, J. D., Kirchhoff, T., Tomsho, L. P., Nafa, K., Pierce, H., Low, M., Satagopan, J., Rennert, H., Huang, H., Greenson, J. K., Groden, J., Rapaport, B., Shia, J., Johnson, S., Gregersen, P. K., … Offit, K. (2002).
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
Laken, S. J., Petersen, G. M., Gruber, S. B., Oddoux, C., Ostrer, H., Giardiello, F. M., Hamilton, S. R., Hampel, H., Markowitz, A., Klimstra, D., Jhanwar, S., Winawer, S., Offit, K., Luce, M. C., Kinzler, K. W., & Vogelstein, B. (1997).