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Orange County Newsroom

City of Hope Orange County leaders and physicians are available to provide commentary on a wide range of healthcare topics and cancer-focused news, trends and research. Interviews with leaders, physicians and patients or visits to the cancer center can be arranged by emailing:
A New City of Hope Orange County Report Reveals Concerning Trends About Cancer in Younger Adults in Southern California

City of Hope Orange County, the most advanced cancer research and treatment organization in Orange County, has released a report that evaluates the cancer incidence rate in people ages 18 and 49 in Orange County and Southern California amid a national epidemic of early-onset cancer diagnoses.

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Younger Face of Cancer

In the News

ESMO 2026: Phase 1 Results of XmAb819, a Novel ENPP3 × CD3 Bispecific, in Advanced Clear Cell Renal Cell Carcinoma (ccRCC)

October 25, 2026

City of Hope's Sumanta Pal, M.D., presented phase 1 results for XmAb819, a novel ENPP3 × CD3 bispecific antibody, in advanced clear cell renal cell carcinoma at the 2026 ESMO Congress. The XmAb819-01 study demonstrated meaningful, dose-dependent antitumor activity with a confirmed objective response rate of 45% at 400 μg/kg. Despite a heavily pretreated patient population, the safety profile was manageable, supporting continued development as monotherapy and potential combination strategies.

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How to Combat the Emotional Rollercoaster of "Scanxiety"

October 23, 2026

The article explores 'scanxiety,' the distress experienced before, during and after cancer-related imaging. City of Hope's Irene Morae Kang, M.D.,details its causes and management. Sheree Santos, a City of Hope patient, shares her journey. Strategies for coping include positive diversions, mindfulness, thought replacement, communication with doctors and support systems, aiming to make clinical settings less scary and more healing for patients.

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Press Releases & Statements

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Hear breakthrough conversations about preventing, treating and curing cancer, brought to you by City of Hope, a National Cancer Institute-designated comprehensive cancer center offering Orange County’s most advanced cancer care. The Science of Cancer Survival Starts Here.

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Orange County Stories

Three women walking together outdoors
Oct 26, 2026
City of Hope Orange County
Breast Cancer Before 40: Changes Younger Women Should Not Ignore
Breast cancer can occur before routine mammograms begin. Know what’s normal for your breasts and speak up when something changes.
Orange County
Patient Care
Gynecologic cancer patient Faten Alsafadi and son Donatello
Oct 23, 2026
City of Hope Orange County
A Son's Love, a Mother's Hope: How One Family’s Search for Answers Led Them to City of Hope Orange County
Lifesaving gynecologic cancer care at City of Hope Orange County transformed this family’s journey.
Orange County
Patient Stories
Breast cancer survivor Caroline de Vaulx at a Pink Dragons dragon boat event
Oct 22, 2026
City of Hope Orange County
After Breast Cancer, She’s Charting New Waters — in a Dragon Boat
City of Hope Orange County grateful patient Caroline de Vaulx discovered a team of breast cancer survivors who helped her move forward, one synchronized stroke at a time.
Orange County
Patient Stories
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Media Gallery

Annette Walker with grateful patients at Breast Cancer Awareness Month celebration
Pacific Symphony performance at a City of Hope event at South Coast Plaza
Dietitian Preeti Soni and chef during a City of Hope cooking demonstration
City of Hope “Hope Is a Rising Tide” art installation
City of Hope blue piano activation at Lido Marina Village

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For media-related questions or inquiries, please contact us at [email protected] or email one of our team members.