Research at City of Hope

The City of Hope 'Difference'
By having scientists, treatment staff and manufacturing facilities side-by-side, our treatment advances can travel from laboratory to patient with lifesaving speed.

At City of Hope, we’re focused on creating miracles of medicine, delivering breakthrough treatment and cures for men, women and children around the world. Originating those breakthroughs relies on the exceptional talents of people with unsurpassed commitment. Exactly the kind of people who are at the heart of our multiple research institutes, centers and programs. As an independent biomedical, treatment and education center, City of Hope's infrastructure and collaborative energy set us apart, converting bold ideas into powerful new treatments with amazing speed.

We are home to Beckman Research Institute of City of Hope, the first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation. It is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.

Recognizing our team’s accomplishments in cancer research, treatment, patient care, education and prevention, the National Cancer Institute has designated City of Hope as a comprehensive cancer center. This is an honor reserved for only 47 institutions nationwide. Our five Cancer Center Research Programs run the gamut from basic and translational studies, to Phase I and II clinical protocols and follow-up studies in survivorship and symptom management.

City of Hope’s Diabetes & Metabolism Research Institute offers a broad diabetes and endocrinology program combining groundbreaking research, unique treatments and comprehensive education to help people with diabetes and other endocrine diseases live longer, better lives.

Our dedicated, multidisciplinary team of healthcare professionals at the Hematologic Malignancies & Stem Cell Institute combine innovative research discoveries with superior clinical treatments to improve outcomes for patients with hematologic cancers.

Working closely with the City of Hope comprehensive cancer center's Developmental Cancer Therapeutics Program and other cancer centers, the Medical Oncology & Therapeutics Research multidisciplinary program includes basic, translational and clinical research and fosters collaborations among scientists and clinicians.

City of Hope's Radiation Oncology Department is on the forefront of improving patient care, and our staff is constantly studying new research technologies, clinical trials and treatment methods that can lead to better outcomes and quality of life for our patients.

Points of Distinction

  • City of Hope is a founding member of the National Comprehensive Cancer Network, meaning our research and treatment protocols advance care throughout the nation.
  • City of Hope is part of ORIEN (Oncology Research Information Exchange Network), the world's largest cancer research collaboration devoted to precision medicine.
  • We have not one, but three, manufacturing facilities on campus that manufacture both biologic/cellular therapeutics and chemical compounds to good manufacturing practice (GMP) standards, quickly turning breakthrough discoveries into lifesaving therapies.
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine, such as helping launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
  • Our research underlies widely-used cancer fighting drugs including Herceptin, Rituxan and Avastin.
  • Holding more than 300 patents, City of Hope submits nearly 30 applications per year to the Food and Drug Administration for investigational new therapies: they’re outstanding numbers for an organization of City of Hope’s size, reflecting our dedication to innovation and speeding treatments to patients.


  • Research Shared Resources and Services - City of Hope embodies the spirit of scientific collaboration by constantly sharing leading-edge services and research facilities with researchers here and around the world, providing access to specialized equipment, laboratories, expertise and resources such as the Graff Medical and Scientific Library.
  • Clinical Trials - Research studies involving volunteer patients are a crucial component in developing new, more effective lifesaving treatments. Our Phase I Clinical Trials Program is constantly investigating new and experimental cancer medicines, novel treatment combinations and other therapeutic methods.
  • Research Operations - City of Hope’s Research Operations team works collaboratively to provide timely and excellent operational and regulatory services to basic, translational and clinical research programs.

Centers and Programs

From clinical trials of drugs and treatments to studies on cancer survivorship, the multidisciplinary teams of basic, clinical and population science investigators collaborating at City of Hope are improving the lives of patients globally.

City of Hope Alpha Clinic

City of Hope Alpha Clinic is a novel program dedicated to the rapid research and development of stem cell-based therapies for cancer, HIV/AIDS and other diseases.

The Judy and Bernard Briskin Center for Multiple Myeloma Research

The Judy & Bernard Briskin Center for Multiple Myeloma Research was established to improve treatment and advance research for patients battling multiple myeloma, lymphoma, leukemia, and other hematologic diseases.

Cancer and Aging Research Program

We unite investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer.

CAR-T Cell Therapy for Brain Tumors

Although CAR-T cell therapy is still being studied, it is already showing enormous potential as a treatment for hard-to-treat cancers such as brain tumors. City of Hope clinicians and researchers are continually evaluating and improving this therapy so it can be more effective and accessible for our patients.

Center for Gene Therapy

We are very excited about the vast potential of stem cell-based therapies to save lives and fundamentally change the way we treat cancer, diabetes, AIDS and many other diseases. The Center for Gene Therapy is dedicated to unlocking that potential through world-class research, and converting that knowledge into real-world treatments and cures as rapidly as possible.

Diabetes & Metabolism Research Institute

City of Hope’s Diabetes & Metabolism Research Institute offers a broad diabetes and endocrinology program combining groundbreaking research, unique treatments and comprehensive education to help people with diabetes and other endocrine diseases live longer, better lives.

Fibromyalgia Research

Since 2005, our Fibromyalgia Research Fund has been supporting a specific research project on fibromyalgia enrolling patients from the fibromyalgia clinic of Dr. R. Paul St. Amand AMD, collecting blood samples from FMS patients and their parents.

Morris Lab

The Morris Laboratory is interested in determining how ncRNAs regulate gene expression and dictate epigenetic states and to what extent this mechanism is operative in shaping the content and architecture of the human genome. Specifically we wish to apply this knowledge to transcriptionally control HIV-1, cancer, and diseases such as Cystic Fibrosis.

Program in Natural Therapies

City of Hope scientists believe numerous medicinal compounds exist in nature that are yet to be discovered. By evaluating a vast array of natural products to identify anti-cancer properties, we’re isolating, purifying, testing and using them as building blocks for more effective, less toxic treatments.

Superfoods Research

Our researchers are finding promising possibilities in certain "superfoods" that may have the ability to combat cancer.