Research Overview

The City of Hope 'Difference'

As an independent biomedical, treatment and education center, City of Hope's infrastructure and collaborative energy set us apart. By having scientists, treatment staff and manufacturing facilities side-by-side, our treatment advances can travel from laboratory to patient with lifesaving speed.

  • Beckman Research Institute: We are home to Beckman Research Institute of City of Hope, the first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation. It is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.
  • Comprehensive Cancer Center: Recognizing our team’s accomplishments in cancer research, treatment, patient care, education and prevention, the National Cancer Institute has designated City of Hope as a comprehensive cancer center. This is an honor reserved for only 48 institutions nationwide. Our five cancer center research programs run the gamut from basic and translational studies, to phase I and II clinical protocols and follow-up studies in survivorship and symptom management.
  • Diabetes & Metabolism Research Institute: The Diabetes & Metabolism Research Institute at City of Hope offers a broad diabetes and endocrinology program combining groundbreaking research, unique treatments and comprehensive education to help people with diabetes and other endocrine diseases live longer, better lives.
  • Hematologic Malignancies and Stem Cell Transplantation Institute: Our dedicated, multidisciplinary team of health care professionals at the institute combine innovative research discoveries with superior clinical treatments to improve outcomes for patients with hematologic cancers.
    • The Judy and Bernard Briskin Center for Multiple Myeloma Research was established to improve treatment and advance research for patients battling multiple myeloma.
    • Center for Gene Therapy: We are very excited about the vast potential of stem cell-based therapies to save lives and fundamentally change the way we treat cancer, diabetes, AIDS and many other diseases. The Center for Gene Therapy is dedicated to unlocking that potential through world-class research, and converting that knowledge into real-world treatments and cures as rapidly as possible.
      • City of Hope Alpha Clinic: The mission of the City of Hope Alpha Clinic, part of the California Institute for Regenerative Medicine Alpha Stem Cell Clinic Network, is to accelerate stem cell-based clinical therapies in regenerative medicine, with a goal of transitioning new disease treatments into sustainable patient care programs for the people of California.
      • The Morris Laboratory is interested in determining how ncRNAs regulate gene expression and dictate epigenetic states and to what extent this mechanism is operative in shaping the content and architecture of the human genome. Specifically we wish to apply this knowledge to transcriptionally control HIV-1, cancer and diseases such as cystic fibrosis.
  • Cancer and Aging Research Program: This program unites investigators from all cancer disciplines to study biology, treatment and survivorship issues that older adults with cancer face.
  • CAR-T Cell Therapy for Brain Tumors: Although CAR-T cell therapy is still being studied, it is already showing enormous potential as a treatment for hard-to-treat cancers such as brain tumors. City of Hope clinicians and researchers are continually evaluating and improving this therapy so it can be more effective and accessible for our patients.
  • Our Fibromyalgia Research Fund has been supporting a specific research project on fibromyalgia, enrolling patients from the fibromyalgia clinic of Paul St. Amand, M.D., and collecting blood samples from fibromyalgia syndrome patients and their parents.
  • Islet Cell Transplantation Program: By sharing its unique resources and expertise throughout southern California, the Islet Cell Transplantation Program aims to address islet transplantation challenges, catalyzing scientific advancements.
  • Jacki and Bruce Barron Cancer Research Scholars Program: The goal of this program is to foster innovative collaborative research and promote the exchange of ideas among exceptional researchers in the United States and Israel.
  • Program for Natural Therapies: City of Hope scientists believe numerous medicinal compounds exist in nature that are yet to be discovered. By evaluating a vast array of natural products to identify anti-cancer properties, we’re isolating, purifying, testing and using them as building blocks for more effective, less toxic treatments.
  • Superfoods Research: Our researchers are finding promising possibilities in certain "superfoods" that may have the ability to combat cancer.

 

Points of Distinction

  • City of Hope is a founding member of the National Comprehensive Cancer Network, meaning our research and treatment protocols advance care throughout the nation.
  • City of Hope is part of ORIEN (Oncology Research Information Exchange Network), the world's largest cancer research collaboration devoted to precision medicine.
  • We have not one, but three, manufacturing facilities on campus that manufacture both biologic/cellular therapeutics and chemical compounds to GMP (good manufacturing practice) standards, quickly turning breakthrough discoveries into lifesaving therapies.
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine, such as helping launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
  • Our research underlies widely-used cancer fighting drugs including Herceptin, Rituxan, Erbitux and Avastin.
  • Holding more than 300 patents, City of Hope submits nearly 30 applications per year to the Food and Drug Administration for investigational new therapies: They’re outstanding numbers for an organization of City of Hope’s size, reflecting our dedication to innovation and speeding treatments to patients.
     

Resources

  • Research Shared Resources and Services - City of Hope embodies the spirit of scientific collaboration by constantly sharing leading-edge services and research facilities with researchers here and around the world, providing access to specialized equipment, laboratories, expertise and resources such as the Graff Medical and Scientific Library.
  • The Center for Biomedicine & Genetics is a California-licensed, 20, 000 square foot, multiproduct biologics manufacturing facility. With 12 ISO 7 production rooms in three product type “zones”, a dedicated aseptic fill suite and a staff with extensive biopharmaceutical experience, the center is capable of producing virtually any type of biologic at scales suitable for phase I through phase II clinical trials.
  • The Biological & Cellular GMP Manufacturing Facility is dedicated to facilitating phase I/II clinical development of innovative biologics through collaboration or contract with academic and corporate groups across the U.S.
  • Clinical Trials - Research studies involving volunteer patients are a crucial component in developing new, more effective lifesaving treatments. Our Phase I Clinical Trials Program is constantly investigating new and experimental cancer medicines, novel treatment combinations and other therapeutic methods.
  • Research Operations - City of Hope’s Research Operations team works collaboratively to provide timely and excellent operational and regulatory services to basic, translational and clinical research programs.