Close-up of sample being place into microplate

Overview

The Becker lab focuses on novel therapy of acute myeloid leukemia (e.g.-RNA therapeutics) and drug resistance in blood cancers (e.g.-acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma) based on clinical features, mutations, and gene expression, with use of high throughput functional screening/multicolor flow cytometry to directly assay drug response.

Principle Investigator: Pamela Becker M.D., Ph.D.

Dr. Pamela Becker is a highly experienced physician-researcher with expertise in hematological malignancies. She aims to translate research breakthroughs into health solutions and to improve therapy for blood cancers.

Full Bio

Lab Members

Brenda Loera

Research Associate

Brenda earned her B.S. in Molecular, Cell, and Developmental Biology from UC Santa Cruz in 2020. She joined the Becker Lab as a research associate in 2022. Her work has primarily been focused on researching RNA therapeutics for Acute Myeloid Leukemia.

Join Our Team

Join one of our labs and help us on our mission to save lives.

Partnerships

Who We Partner With

These organizations are invaluable partners in our work toward progressing the development of new treatments in our specialized areas of research.

NIH-NCI

Leukemia Lymphoma Society

Israel Cancer Research Fund

Toni Stephenson Lymphoma Center

Stop Cancer

Our Publications

Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function. Cell Stem Cell.

Reilly A, Philip Creamer J, Stewart S, Stolla MC, Wang Y, Du J, Wellington R, Busch S, Estey EH, Becker PS, Fang M, Keel SB, Abkowitz JL, Soma LA, Ma J, Duan Z, Doulatov S.

Phase 1/2 study of uproleselan added to chemotherapy in patients with relapsed or refractory acute myeloid leukemia..

DeAngelo DJ, Jonas BA, Liesveld JL, Bixby DL, Advani AS, Marlton P, Magnani JL, Thackray HM, Feldman EJ, O'Dwyer ME, Becker PS.

Custom High Throughput Drug Sensitivity Assay Reveals Therapeutic Options for Chronic Myeloid Leukemia Patients Resistant to or Intolerant of Tyrosine Kinase Inhibitors.

Vivian G. Oehler, Sylvia Chien, Jin Dai, Carrie L. Cummings, James Annis, Timothy J Martins, Pamela S. Becker

High-Throughput Drug Screening and Multi-Omic Analysis to Guide Individualized Treatment for Multiple Myeloma.

Coffey DG, Cowan AJ, DeGraaff B, Martins TJ, Curley N, Green DJ, Libby EN, Silbermann R, Chien S, Dai J, Morales A, Gooley TA, Warren EH, Becker PS.

A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia.

Lee SI, Celik S, Logsdon BA, Lundberg SM, Martins TJ, Oehler VG, Estey EH, Miller CP, Chien S, Dai J, Saxena A, Blau CA, Becker PS.

Sparse expression bases in cancer reveal tumor drivers.

Logsdon BA, Gentles AJ, Miller CP, Blau CA, Becker PS, Lee SI.