Active Support
The Department of Diabetes & Cancer Discovery Science has a grant portfolio of $24,536,530 million in active support, funded by the National Institute of Diabetes and Digestive and Kidney Diseases. Currently funded grants are:
Integrated Islet Distribution Program (IIDP) (2021 – 2026)
The IIDP serves the biomedical research community by providing investigators with access to human islets to enhance knowledge of islet cell biology. Project goals include: 1) to establish a coordinating center that provides for the distribution of human cadaveric islets for laboratory research, 2) to assure continued islet availability to the medical research community, and 3) to develop and maintain a financial system that both collects and disburses respective receivables and expenditures. For this project, Joyce Niland, Ph.D., Estelle & Edward Alexander Chair in Information Sciences, led the development of a unique automated web-based islet distribution system that optimizes the availability of high-quality islets for approved investigators nationwide, and monitors and balances the supply-and-demand ratio. Several publications have resulted from this initiative, and a robust validated shipping methodology to avoid degradation of the islets during transport has been developed and published.
(Total awarded 2021 - 2026: $14.9 million; $40 million total awards over 10 years)
The IIDP serves the biomedical research community by providing investigators with access to human islets to enhance knowledge of islet cell biology. Project goals include: 1) to establish a coordinating center that provides for the distribution of human cadaveric islets for laboratory research, 2) to assure continued islet availability to the medical research community, and 3) to develop and maintain a financial system that both collects and disburses respective receivables and expenditures. For this project, Joyce Niland, Ph.D., Estelle & Edward Alexander Chair in Information Sciences, led the development of a unique automated web-based islet distribution system that optimizes the availability of high-quality islets for approved investigators nationwide, and monitors and balances the supply-and-demand ratio. Several publications have resulted from this initiative, and a robust validated shipping methodology to avoid degradation of the islets during transport has been developed and published.
(Total awarded 2021 - 2026: $14.9 million; $40 million total awards over 10 years)
Intestinal Stem Cell Consortium (ISCC) Coordinating Center (2019 – 2024) and ISCC Supplement (2020-2021)
The vision of the ISCC is to develop novel therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine. The mission of the ISCC is to characterize the minimal, required niche factors that support intestinal stem cells in health and disease, using an integrated, multidisciplinary team science approach. The overarching goal is to characterize the minimal, required factors that support ISCs in health and disease, with the following sub-goals:
The vision of the ISCC is to develop novel therapies targeting intestinal stem cells and their supportive niche to regenerate and rebuild the human intestine. The mission of the ISCC is to characterize the minimal, required niche factors that support intestinal stem cells in health and disease, using an integrated, multidisciplinary team science approach. The overarching goal is to characterize the minimal, required factors that support ISCs in health and disease, with the following sub-goals:
- Similarities and differences between the murine and human ISC niche
- ISC niche function in homeostasis and injury
- Identification and validation of strategies to engineer the ISC niche for therapeutic purposes
Under the direction of Joyce Niland, Ph.D., Estelle & Edward Alexander Chair in Information Sciences, the overall objective of the ISCC-CC is to provide optimal infrastructure and administrative support for the ISCC to ensure that the Consortium efficiently and rapidly achieves its goals.
(Total currently awarded: Parent - $2,029,255 and Supplement - $89,267)
(Total currently awarded: Parent - $2,029,255 and Supplement - $89,267)
Human Islet Research Enhancement Center (HIREC) Coordinating Center (2019 – 2024)
City of Hope serves as the Human Islet Research Enhancement Center (HIREC), to support the goal of the Human Islet Research Network (HIRN) to develop innovative strategies for the treatment, prevention and cure of type 1 diabetes (T1D). HIREC, led by Co-Principal Investigators Drs. Niland and Kaddis, provides a centralized organizational and administrative infrastructure, an information technology platform, and a research dissemination engine to address the burgeoning needs of the HIRN. To support the HIRN mission, the HIREC with the guidance of the HIRN advisory committees and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and HIRN Trans-Network Committee (TNC).
(Total current award: $7.5 million)
City of Hope serves as the Human Islet Research Enhancement Center (HIREC), to support the goal of the Human Islet Research Network (HIRN) to develop innovative strategies for the treatment, prevention and cure of type 1 diabetes (T1D). HIREC, led by Co-Principal Investigators Drs. Niland and Kaddis, provides a centralized organizational and administrative infrastructure, an information technology platform, and a research dissemination engine to address the burgeoning needs of the HIRN. To support the HIRN mission, the HIREC with the guidance of the HIRN advisory committees and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and HIRN Trans-Network Committee (TNC).
(Total current award: $7.5 million)