City of Hope ® Cancer Center Duarte, a National Cancer Institute (NCI)-designated comprehensive cancer center, located in the San Gabriel Valley, is a hub for leading-edge research and clinical trials, meaning patients receive treatments based on the latest science that is being developed just steps away. This is especially important for advanced or recurrent colon and rectal cancers, which can be more challenging to treat. If you or a loved one is fighting colon or rectal cancer, our team of experts is committed to providing the highest quality care available.

With over 30 clinical network locations throughout the Los Angeles and Southern California region, we are committed to offering continuity of care that supports you at every stage of your colorectal cancer diagnosis, treatment and recovery process.

Colon Cancer and Rectal Cancer Care in Los Angeles

At City of Hope, we use a team-based approach to personalize each patient's treatment plan according to their unique situation. Our nationally renowned physicians work closely with patients and their families to ensure that they receive compassionate and dignified care. Our team of experts includes colorectal surgeons, oncologists, gastroenterologists, radiologists and pathologists, along with nurses, genetic counselors, nutritionists and specially trained support staff. Our comprehensive approach means better care and a strong potential for improved outcomes.

What Sets Our Los Angeles-Area Colorectal Cancer Program Apart?

The Colorectal Cancer Program at City of Hope is staffed by highly skilled surgeons who specialize in leading-edge techniques such as robotic and laparoscopic surgeries, which are less invasive and gentler on patients' bodies. The program also offers advanced diagnostic tools, genetic testing to determine a tumor's specific biology and design targeted treatments that can prevent its growth.

  • If you're receiving treatment for colorectal cancer at City of Hope, you'll be near our research labs, where new treatments are being developed every day. This means that you'll have access to a unique form of cancer care known as bench-to-bedside treatment. This involves rapidly moving the exciting new research being conducted in our labs to the bedside to treat our patients. Our patients can enroll in City of Hope's ongoing clinical trials for immunotherapy, including bispecific antibodies and combination checkpoint inhibitors for MSS colorectal cancer that has progressed on systemic chemotherapy. Learn more about our clinical trials.
  • We focus on precision medicine, using minimally invasive surgical techniques and testing individual cancer cells to find the best drug combinations for each patient's specific cancer. 
  • We have expertise in hereditary/familial cancer syndromes, with next-generation DNA sequencing to define the current and future risks for all potentially affected family members.
  • We target therapy to individual patients, and we have many options for treating complex colorectal cancers, including sphincter-saving surgery, which reduces the need for a permanent colostomy.
  • We offer hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC) to surgically remove widespread cancer and deliver heated chemotherapy directly to the abdomen.
  • Our colorectal surgeons specialize in complicated, advanced-stage or recurrent cancers and work with our liver surgery team to perform combined colon and liver operations. They also collaborate with our urologists and gynecologists for combined pelvic operations affecting the rectum, bladder, prostate or female organs.
  • Our superior colorectal cancer outcomes are reflected in its survival rates, which are among the best in the greater Los Angeles region for all stages of colorectal cancer.
  • We also emphasize the importance of prevention and screening, offering colonoscopies, stool DNA testing and genetic screening to increase the chances of detecting colorectal cancer at an early stage.
  • Additionally, our patients receive ongoing support throughout their treatment and beyond, including help adjusting to post-treatment diet and lifestyle changes.

Our Los Angeles-Area Colorectal Cancer Program Recognitions

City of Hope is ranked among the Highest Performing Hospitals for Colon Cancer Surgery by U.S. News & World Report 2024-25


U.S. News & World Report has ranked City of Hope Duarte as a “high performing” for colon cancer surgery and as one of America’s top cancer hospitals overall for nearly two decades. 

Our Los Angeles-Area Colorectal Cancer Experts

Colorectal Cancer Leadership

Make an Appointment with Our Los Angeles-Area Colorectal Cancer Team

Expertise Matters

The world-renowned team at City of Hope offers a deep understanding of the latest colorectal cancer treatments. Our expertise comes from treating cancer, including rare and complex cases, every day.
 

Call to become a patient, get a second opinion, or make a referral. For international patients, please visit the Center for International Medicine.

The City of Hope Duarte campus