San Fernando Valley Exceptional Cancer Care

With nine locations throughout the San Fernando Valley, City of Hope® offers our patients access to comprehensive, expert cancer care closer to home. City of Hope is committed to ensuring that you receive high-quality clinical care and emotional and physical support throughout your cancer journey.

We have five full-service cancer clinics in the San Fernando Valley, where a team of skilled doctors and the health care professionals work together to provide caring and personalized support. Our team includes surgeons, medical oncologists, radiation therapists, oncology nurses and other cancer experts focused on offering the best treatment options available, including access to new and innovative clinical trials. Our clinical team and staff speak multiple languages, ensuring you can fully participate in your care.

City of Hope’s radiation oncology department, the largest network of its kind in Southern California, offers radiation therapy care at four dedicated San Fernando Valley facilities. These facilities are certified by the American Society for Radiation Oncology’s Accreditation Program for Excellence® (APEx). APEx accreditation is based on performance in 16 safety protocols and ensures that recognized facilities consistently meet the highest levels of patient care and safety.

Getting a Second Opinion

Choosing a cancer expert to care for you during your cancer journey is crucial. Many people find it helpful to get a second opinion about their diagnosis and treatment options before making a final decision. When you come to City of Hope for a second opinion at one of our San Fernando Valley locations, our cancer specialists will work quickly to evaluate your situation carefully. We will create a treatment plan tailored just for you based on your specific diagnosis and personal needs.

Female Consultation

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Triumphant smile of Natasha Shows, a City of Hope of breast cancer survivor, standing in a in a wildflower-filled meadow
When I was diagnosed with cancer, there was just no doubt in my mind that I was going to City of Hope."
Natasha Shows
Breast Cancer Survivor

Why Choose City of Hope for Your Cancer Treatment?

City of Hope's mission is to transform hope into reality for everyone affected by cancer and diabetes. Founded in 1913, City of Hope has developed into one of the largest and most advanced cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses.

2025-2026 US News Best Cancer Hospitals

At the center of City of Hope is an independent, National Cancer Institute-designated comprehensive cancer center in Duarte, near Los Angeles. U.S. News & World Report ranked City of Hope Duarte among the Top Five in the nation for cancer care, earning it the highest such ranking in California.

City of Hope’s uniquely integrated model encompasses cancer care, research and development, academics and training, and a robust philanthropy program that fuels its efforts. City of Hope’s expanding national system includes its Los Angeles campus, a network of clinical care locations throughout Southern California, a new cancer center in Orange County, California, and cancer treatment centers and outpatient facilities in Arizona, Illinois and Georgia. 

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Meet Gynecologic Oncologist Wei-Chien Michael Lin, M.D.
It’s important to show (patients) that there’s light at the end of the tunnel ... that these diseases are treatable and people can beat the odds and survive and live a meaningful, productive life.”
Wei-Chien Michael Lin, M.D.
Gynecologic Oncologist at City of Hope Mission Hills and Santa Clarita

Where to Find Us in the San Fernando Valley

Schedule an Appointment Now

Being diagnosed with cancer is stressful. Getting access to clinical experts and leading-edge treatment offerings personalized to your needs shouldn’t be.