
Ajay Goel Lab
Research Highlights
Biomarkers for Diagnosis, Prognosis, Treatment Response and Monitoring

Using a multiplicity of molecular approaches, City of Hope researchers have identified a diverse range of novel colorectal cancer biomarkers, including DNA, mRNA, microRNA and DNA methylation-based biomarkers. The potential clinical applications of these biomarkers are broad, and include diagnosis, prognosis, treatment prediction and monitoring of colorectal and other GI cancers, as well as patient stratification for clinical trials.
Notably, most of these biomarkers have been validated using clinical samples from large patient cohorts and have been described in highly regarded peer-reviewed journals. These biomarkers offer three benefits that are key to clinical and commercial success:
- Multiple applications – novel, proprietary biomarkers for diagnosis, prognosis and monitoring of colorectal and other GI cancers
- Stand-alone or multiplexed – the biomarkers can potentially be used in stand-alone assays, or as part of multiplexed assays to achieve greater sensitivity and specificity
- Integration – the biomarkers are compatible with standard molecular platforms and workflows
Epigenetics and Cancer Prevention
Resources available:

- Ion Torrent PGM sequencer
- Ion Chef
- Applied Biosystems 3100 Avant sequencer
- Pyromark PSQ HS 96A pyrosequencing system
- QiaCube automated nucleic acid extraction systems
- QuantStudio digital PCR system
- Applied Biosystems real-time PCR machines
- Fluorescence microscopes
- Digital imaging systems
Professor and Chair in the Department of Molecular Diagnostics and Experimental Therapeutics and Associate Director of Basic Science in the Comprehensive Care Center, Ajay Goel's research focuses on better methods for the early detection and precision treatment of cancer.

Lab Members


Yudai Higuchi is a Global Scholar in the Ajay Goel Lab at City of Hope.


Maaha Khan is a Research Associate I and Lab Manager in the Ajay Goel Lab at City of Hope. Maaha Khan graduated from McGill University with a B.S. in Biology and Mathematics with concentrations in Neuroscience and Statistics. During her undergraduate degree, she had multiple research internships where she worked on projects focusing on lymphocytic lymphoma and immune cell states in brain tumors. In her free time, she enjoys dancing and going to the beach.


Xin Kong, Ph.D., holds a Ph.D. in Biology from University of Science and Technology of China (USTC), and works in the Subspecialty of Molecular Pathology at the Department of Pathology, The First Affiliated Hospital of USTC. She is specializing in the tumor molecular diagnostic and genetic consulting. Outside of work, she enjoys sports and traveling.


Yuan Li, a Ph.D. candidate at Tongji University, is dedicated to her current research, which revolves around understanding the intricacies of gastrointestinal cancer metastasis and the development of resistance to cancer treatments.
Her main goal is to enhance the understanding of molecular and immune biomarkers present in tissue and blood samples. This work aims to improve the accuracy of precision diagnostics and treatment strategies for gastrointestinal cancer.
Outside of her research endeavors, she finds joy in activities such as hiking and traveling.


Takayuki Noma, M.D., graduated from Tokushima University of Medicine in Japan. In Japan he worked as a digestive surgeon.
He played rugby football at university and enjoys fishing and cooking.


Roxanna Razavi is a Research Associate I in the Goel Lab at City of Hope. Roxanna graduated from the University of California- Santa Barbara with a B.S. in Biological Sciences and Honors Distinction in Research. During her undergraduate degree, she gained experience in various labs and primarily focused on investigating the effects of a ketogenic diet on liver cysts in autosomal dominant polycystic kidney disease (ADPKD). Outside of the lab, she enjoys practicing yoga and attending concerts.


Silei Sui graduated from Dalian Medical University with a Ph.D. in oncology and worked on the molecular mechanism and clinical significance of colorectal cancer before joining City of Hope. After graduation, she worked as a visiting postdoctoral under the guidance of Ajay Goel, Ph.D., M.S., at City of Hope. She aims to identify clinical biomarkers for improving the survival and treatment effect of colorectal cancer based on a multi-omics NGS approach.
Sui is skilled in Python, R, and machine learning and experienced in the biological analysis of genome sequencing, transcriptional sequencing and single-cell sequencing data.
Outside of work, she enjoys fitness and listening to music.


Toshiaki Takahashi, M.D. graduated from Okayama University in Japan and is currently affiliated with the Department of Gastroenterological Surgery at Okayama University. His research focuses on translational oncology. Outside of his academic and research pursuits, Dr. Takahashi enjoys both playing and watching sports.


Koichi Takiguchi, MD, Ph.D. is a global scholar in the Ajay Goel Lab at City of Hope, Duarte, CA. He graduated from Fukushima Medical University in Japan and belong to the First Department of Surgery, Faculty of Medicine, University of Yamanashi. He is a gastrointestinal surgeon specializing in the lower gastrointestinal tract.


Junyong Weng, M.D. Ph.D. is a Global Scholar in the Ajay Goel Lab at City of Hope, Duarte, CA. Junyong Weng, M.D., Ph.D, earned a Ph.D. from Fudan University, specializing in metastatic colorectal cancer and immunotherapy research. During his time at City of Hope, under the mentorship of Professor Goel, he focuses on developing biomarkers for predicting treatment responses in colorectal cancer and identifying potential therapeutic targets. Outside of work, he enjoys staying active through sports and exploring his passion for cooking.


Lingling Xu is a Global Scholar in the Ajay Goel Lab at City of Hope.


Yang Yang is a Global Scholar in the Ajay Goel Lab at City of Hope.


Jiabei Zhu, Ph.D., earned her Ph.D. from Shanghai Jiao Tong University School of Medicine, specializing in the role of noncoding RNAs in the development of liver cancer. During her time at City of Hope, under the mentorship of Professor Goel, she focuses on investigating the role of small ncRNAs in liver cancer pathogenesis and developing biomarkers for liver cancer diagnosis. Outside of work, she enjoys staying active through sports and traveling.
Current Funding
These organizations are invaluable partners in our work toward progressing the development of new treatments in our specialized areas of research.

Our Publications
Latest Research News

The researchers looked at 210 plasma samples from pancreatic ductal adenocarcinoma patients, some of whom had neoadjuvant treatment (NAT) ...

Dr. Ajay Goel highlighted the importance of colon cancer screenings and provided insight on the new screening guidelines for patients.

DDW 2021 abstract - Transcriptomic Profiling Identifies a Risk Stratification Signature for Predicting Peritoneal Recurrence and Micrometastasis in Gastric Cancer

According to the American Cancer Society, there will be about 150,000 new cases of colon cancer this year alone, and more than 50,000 deaths.

Assessment of the Diagnostic Efficiency of a Liquid Biopsy Assay for Early Detection of Gastric Cancer
Contact Information
The Goel Lab is expanding! We are hiring Global Scholars, Postdoctoral Fellows, and Research Associates to be part of our dynamic, multidisciplinary research group led by Dr. Ajay Goel, Professor and Chair of the Department of Molecular Diagnostics and Experimental Therapeutics, and Associate Director of Basic Sciences at City of Hope Comprehensive Cancer Center.
Our collaborative team includes basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, working on groundbreaking projects within large international consortia. Our lab focuses on translational research in the genomic and epigenomic characterization of gastrointestinal (GI) cancers, including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers.
If you're passionate about advancing cancer research and working in a cutting-edge scientific environment, we’d love to hear from you! Please send your resume to [email protected].
34.1381007, -118.0199764
Monrovia, CA 91016