Islet Isolation & Distribution

Islet Distribution Map
The Southern California Islet Cell Resource (SC-ICR) Center  was established at City of Hope in 2001. The SC-ICR manufactures human islets from cadaveric donor pancreata for clinical and basic science research. The SC-ICR is currently contracted to distribute islets nationally under the National Institutes of Health-funded (NIH) Integrated Islet Distribution Program.
Scientists conducting islet research can apply to receive islets through the website of the National Institutes of Health-funded Integrated Islet Distribution Program (IIDP).

Human Islet Isolation
Human islets are prepared at Beckman Research Institute of City of Hope in association with the Center for Biomedicine & Genetics, a clinical Good Manufacturing Procedures (cGMP)-compliant facility located on City of Hope’s Duarte campus.

The methodology for preparation of human islets for clinical transplantation have been reviewed and approved by the Food and Drug Administration under City of Hope’s Drug Master File.

Human Islet Culture
Following isolation and prior to shipment, human islets are cultured for up to 72 hours.

Human Islet Distribution
The SC-ICR has been preparing and distributing human islets to support important diabetes research across the country since January 2002, and has been one of the nation’s leading islet distributors ever since City of Hope islets for research are distributed according to the shipping procedures approved under the NIH Integrated Islet Distribution Program (IIDP). In the most recent fiscal reporting period, City of Hope was hailed for having produced nearly 4 million islets for research, with over 3.4 million of those islets distributed to researchers through the IIDP system. This ranked City of Hope second in the nation for both production and distribution.
In addition, the 95.9 percent of the islets processed and distributed by City of Hope were ranked as excellent or good in quality by the researchers who received them, making City of Hope islets the highest quality in the nation.
Last update October 2013