CAR T Cell Therapy for Cancer
One of the most promising areas of cancer research and treatment is known as immunotherapy, in which a patient’s own immune system is enlisted in the fight against cancer. This approach is more than just a narrow field of study at City of Hope. It is the central component of groundbreaking research and clinical trials currently underway.
City of Hope continues to be at the forefront of a powerful form of immunotherapy known as chimeric antigen receptor (CAR) T cell therapy. Using this approach, immune cells are taken from a patient’s bloodstream, reprogrammed to recognize and attack a specific protein found in cancer cells, then reintroduced into the patient’s system, where they get to work destroying targeted tumor cells.
City of Hope is leading the way in advancing CAR T therapies by:
- Applying our proprietary CAR T technology in active preclinical and clinical programs across a range of hematologic cancers and solid tumors
- Partnering with global biopharmaceutical companies to make their therapies available to patients
- Collaborating with other academic researchers to advance clinical research in areas of high unmet medical need
What is CAR T Cell Therapy?
Our history with CAR T cell therapy dates back to the late 1990s and builds on Stephen J. Forman, M.D.’s pioneering work in bone marrow transplantation (BMT). The City of Hope BMT program began in 1976 and has since grown into one of the largest, most successful programs of its kind in the nation. To date, more than 14,000 bone marrow transplants have been performed at City of Hope, with survival rates exceeding expectations for 13 consecutive years.
How CAR T cell therapy works, as explained by Saul Priceman, Ph.D.
City of Hope, with its clinical care, research and production facilities all on one campus, is uniquely positioned to lead this work. Few institutions are capable of harnessing the same comprehensive “bench to bedside” resources necessary for the discovery, translational research, clinical development, manufacturing, quality assurance and delivery of leading-edge treatments for our patients. City of Hope has the ability to harvest, reprogram, multiply and deliver T cells all on the same campus.
Key to City of Hope’s success in advancing lifesaving CAR T cell therapy is our legacy of patient-centered care — treating not just the illness but caring for the entire patient. Our community includes researchers, scientists, doctors, nurses and supportive care professionals, each of whom is dedicated to giving patients the chance to live longer, better and more fully.